五千年来，因血魔作祟，附于有权势之人身上，历代暴君，置人民于水深火热中，血流成河，无名英雄引血魔为伏羲针所镇，此举必需牺牲自己生命。文化大革命爆发，破四旧运动令本来深埋黑洞里的血魔逃出，自小有心脏病的红卫兵梁国栋（梁家辉饰）与赤脚医生林刚（林正英饰），因“运动”而对立，但在生离死别、家破人亡之后，两人误会冰释，联手与血魔对抗。
血魔附于革委副主任雷复鸣身上，雷性情大变。其女雷珊（王祖贤饰），与栋及刚又有微妙三角关系，三人一起与血魔展开决战，林刚目睹文革毒害，不但丧失一代文化精英，且举国人魔不分，尸横遍野，终看破红尘，斩断情缘，成全手足 [1]。
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